Synthesis and antimycobacterial activity of bornylamine derived amido-alcohols
نویسندگان
چکیده
Three novel amido-alcohols were synthesized on the base of the camphane scaffold. Natural amino acids were transformed into their -hydroxy analogues with retention of configuration, and attached to bornylamine. The compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv. The activity shifts from micromolar to nanomolar inhibitory concentrations depending on the -hydroxy acid moiety. The valine derived compound demonstrates activity 25 times higher than the referent ethambutol. The amido-alcohols with camphane scaffolds emerge as promising new class of antimycobacterial agents.
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